The Ha Luminosity Function and Star Formation Rate at z\sim 0.2

We have measured the Ha+[N II] fluxes of the I-selected Canada-France Redshift Survey (CFRS) galaxies lying at a redshift z below 0.3, and hence derived the Ha luminosity function. The magnitude limits of the CFRS mean that only the galaxies with M(B) > -21 mag were observed at these redshifts. We obtained a total Ha luminosity density of at least 10^{39.44\pm 0.04} erg/s/Mpc^{3} at a mean z=0.2 for galaxies with rest-fame EW(Ha+[N II]) > 10 Angs. This is twice the value found in the local universe by Gallego et al. 1995. Our Ha star formation rate, derived from Madau (1997) is higher than the UV observations at same z, implying a UV dust extinction of about 1 mag. We found a strong correlation between the Ha luminosity and the absolute magnitude in the B-band: M(B(AB)) = 46.7 - 1.6 log L(Ha). This work will serve as a basis of future studies of Ha luminosity distributions measured from optically-selected spectroscopic surveys of the distant universe, and it will provide a better understanding of the physical processes responsible for the observed galaxy evolution.Comment: Accepted for publication in ApJ, 14 pages, LaTeX (macro aas2pp4.sty), 6 figure

Dipole anisotropies of IRAS galaxies and the contribution of a large-scale local void

Recent observations of dipole anisotropies show that the velocity of the Local Group (\Vec v_{\rm G}) induced by the clustering of IRAS galax ies has an amplitude and direction similar to those of the velocity of Cosmic Microwave Background dipole anisotropy (\Vec v_{\rm CMB}), but the difference | \Vec v_{\rm G} - \Vec v_{\rm CMB} | is still $\sim 170$ km/s, which is about 28% of |\Vec v_{\rm CMB} |. Here we consider the possibility that the origin of this difference comes from a hypothetical large-scale local void, with which we can account for the accelerating behavior of type Ia supernovae due to the spatial inhomogeneity of the Hubble constant without dark energies and derive the constraint to the model parameters of the local void. It is found as a result that the distance between the Local Group and the center of the void must be $(10 -- 20) h^{-1}$ Mpc, whose accurate value depends on the background model parameters.Comment: 13 pages, 1 figure, to be published in ApJ 584, No.2 (2003

The Gaseous Extent of Galaxies and the Origin of \lya Absorption Systems. III. Hubble Space Telescope Imaging of \lya-Absorbing Galaxies at z < 1

We present initial results of a program to obtain and analyze HST WFPC2 images of galaxies identified in an imaging and spectroscopic survey of faint galaxies in fields of HST spectroscopic target QSOs. We measure properties of 87 galaxies, of which 33 are associated with corresponding \lya absorption systems and 24 do not produce corresponding \lya absorption lines to within sensitive upper limits. Considering only galaxy and absorber pairs that are likely to be physically associated and excluding galaxy and absorber pairs within 3000 \kms of the background QSOs leaves 26 galaxy and absorber pairs and seven galaxies that do not produce corresponding \lya absorption lines to within sensitive upper limits. Redshifts of the galaxy and absorber pairs range from 0.0750 to 0.8912 with a median of 0.3718, and impact parameter separations of the galaxy and absorber pairs range from 12.4 to $157.4 h^{-1}$ kpc with a median of $62.4 h^{-1}$ kpc. The primary result of the analysis is that the amount of gas encountered along the line of sight depends on the galaxy impact parameter and B-band luminosity but does not depend strongly on the galaxy average surface brightness, disk-to-bulge ratio, or redshift. This result confirms and improves upon the anti-correlation between \lya absorption equivalent width and galaxy impact parameter found previously by Lanzetta et al. (1995). There is no evidence that galaxy interactions play an important role in distributing tenuous gas around galaxies in most cases. Galaxies might account for all \lya absorption systems with $W > 0.3$ \AA, but this depends on the unknown luminosity function and gaseous cross sections of low-luminosity galaxies as well as on the uncertainties of the observed number density of \lya absorption systems.Comment: Minor changes. Figure 1 stays intact and is available at ftp://ftp.ess.sunysb.edu/pub/lanzetta/wfpc

Climbing fiber regulation of spontaneous Purkinje cell activity and cerebellum-dependent blink responses

It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active. The cerebellar output will, therefore, depend on how input is integrated into this spontaneous activity. It has been shown that input from climbing fibers originating in the inferior olive controls the spontaneous activity in Purkinje cells. While blocking climbing fiber input to the Purkinje cells causes a dramatic increase in the firing rate, increased climbing fiber activity results in reduced Purkinje cell activity. However, the exact calibration of this regulation has not been examined systematically. Here we examine the relation between climbing fiber stimulation frequency and Purkinje cell activity in unanesthetized decerebrated ferrets. The results revealed a gradual suppression of Purkinje cell activity, starting at climbing fiber stimulation frequencies as low as 0.5 Hz. At 4 Hz, Purkinje cells were completely silenced. This effect lasted an average of 2 min after the stimulation rate was reduced to a lower level. We also examined the effect of sustained climbing fiber stimulation on overt behavior. Specifically, we analyzed conditioned blink responses, which are known to be dependent on the cerebellum, while stimulating the climbing fibers at different frequencies. In accordance with the neurophysiological data, the conditioned blink responses were suppressed at stimulation frequencies of =4 Hz

The Luminosity Function of Field Galaxies in the CNOC1 Redshift Survey

We have computed the luminosity function for 389 field galaxies from the Canadian Network for Observational Cosmology cluster redshift survey (CNOC1), over redshifts z = 0.2-0.6. We find Schechter parameters M^* - 5 log h = -19.6 \pm 0.3 and \alpha = -0.9 \pm 0.2 in rest-frame B_{AB}. We have also split our sample at the color of a redshifted but nonevolving Sbc galaxy, and find distinctly different luminosity functions for red and blue galaxies. Red galaxies have a shallow slope \alpha \approx -0.4 and dominate the bright end of the luminosity function, while blue galaxies have a steep \alpha \approx -1.4 and prevail at the faint end. Comparisons of the CNOC1 results to those from the Canada-France (CFRS) and Autofib redshift surveys show broad agreement among these independent samples, but there are also significant differences which will require larger samples to resolve. Also, in CNOC1 the red galaxy luminosity density stays about the same over the range z = 0.2-0.6, while the blue galaxy luminosity density increases steadily with redshift. These results are consistent with the trend of the luminosity density vs. redshift relations seen in the CFRS, though the normalizations of the luminosity densities appear to differ for blue galaxies. Comparison to the local luminosity function from the Las Campanas redshift survey (LCRS) shows that the luminosity density at z \approx 0.1 is only about half that seen at z \approx 0.4. A change in the luminosity function shape, particularly at the faint end, appears to be required to match the CNOC1 and LCRS luminosity functions, if galaxy evolution is the sole cause of the differences seen. However, it should be noted that the specific details of the construction of different surveys may complicate the comparison of results and so may need to be considered carefully.Comment: 22 pages, including 6 postscript figures, uses AASTEX v4.0 style files. Corrected minor typos and updated references. Results and conclusions unchanged. Final version to appear in the Astrophysical Journa

Nonlinear dynamic analysis of gas turbine combustor leaf seal

The leaf seals are one of the typical sealing systems in gas turbine and jet engines. In Baker Hughes LT family gas turbines, they are used to create sealing between the combustion chamber and the first stage nozzle. The leaf seals are thin metallic plates and subjected to dynamic loads and high temperatures. They have curved contacts, and depending on the inclination, they can experience partial contact. Furthermore, when excited by dynamic loads, the leaf seal can be subject to intermittent contact, possibly triggering wear out or vibratory phenomena. Due to its flexibility and its partial seating, it exhibits a complex nonlinear dynamic behaviour, strongly variable with the operating conditions. This study presents a numerical investigation using coupled static/dynamic harmonic balance method (HBM) frequency-based solution technique. The reported solutions include nonlinear forced response and contact studies for various operating and kinematic conditions along with brief insights

AXL as a modulator of sunitinib response in glioblastoma cell lines

Receptor tyrosine kinase (RTK) targeted therapy has been explored for glioblastoma treatment. However, it is unclear which RTK inhibitors are the most effective and there are no predictive biomarkers available. We recently identified the RTK AXL as a putative target for the pan-RTK inhibitors cediranib and sunitinib, which are under clinical trials for glioblastoma patients. Here, we provide evidence that AXL activity can modulate sunitinib response in glioblastoma cell lines. We found that AXL knockdown conferred lower sensitivity to sunitinib by rescuing migratory defects and inhibiting apoptosis in cells expressing high AXL basal levels. Accordingly, overactivation of AXL by its ligand GAS6 rendered AXL positive glioblastoma cells more sensitive to sunitinib. AXL knockdown induced a cellular rewiring of several growth signaling pathways through activation of RTKs, such as EGFR, as well as intracellular pathways such as MAPK and AKT. The combination of sunitinib with a specific AKT inhibitor reverted the resistance of AXL-silenced cells to sunitinib. Together, our results suggest that sunitinib inhibits AXL and AXL activation status modulates therapy response of glioblastoma cells to sunitinib. Moreover, it indicates that combining sunitinib therapy with AKT pathway inhibitors could overcome sunitinib resistance.This work was funded by Fundacao para a Ciencia e Tecnologia (FCT), Portugal (project: PTDC/SAU-TOX/114549/2009). Olga Martinho is a recipient of a Post-Doc fellowship (UMINHO/BPD/32/2013) from QREN. We would like to acknowledge Dr. Shuang-En Chuang from the National Health Research Institute, Taiwan, for providing AXL vectors, and Dr. Raquel Andrade for critical review of the manuscript